Tumor-Associated Macrophages as Target for Antitumor Therapy
نویسندگان
چکیده
منابع مشابه
Extracellular matrix as target for antitumor therapy
The aim of the present review is to survey the accumulated knowledge on the extracellular matrix (ECM) of tumors referring to its putative utility as therapeutic target. Following the traditional observation on the extensive morphological alteration in the tumor-affected tissue, the well-documented aberrant cellular regulation indicated that ECM components have an active role in tumor progressi...
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Tumor-associated macrophages (TAMs) originate in the circulation and are recruited to the tumor site by specific tumorderived attractants such as monocyte chemotactic protein-1 (1,2). By use of several mechanisms, TAMs bind to the tumor cells via glycoproteins, sugars, and phospholipids and become localized at the tumor–host tissue interface (2,3). Unlike macrophages that are involved in inflam...
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In recent years, the influence of the tumor microenvironment (TME) on cancer progression has been better understood. Macrophages, one of the most important cell types in the TME, exist in different subtypes, each of which has a different function. While classically activated M1 macrophages are involved in inflammatory and malignant processes, activated M2 macrophages are more involved in the wo...
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Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis. In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...
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BACKGROUND Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Tumor-associated macrophages (TAM) have been shown to promote malignant growth and to correlate with poor prognosis. [1,4,7,10-tetraazacyclododecane-NN',N″,N'″-tetraacetic acid]-d-Phe1,Tyr3-octreotate (DOTATATE) labeled with Gallium-68 selectively binds to somatostatin receptor 2A (SSTR2A) which is specif...
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ژورنال
عنوان ژورنال: Archivum Immunologiae et Therapiae Experimentalis
سال: 2017
ISSN: 0004-069X,1661-4917
DOI: 10.1007/s00005-017-0480-8